PARP (Poly ADP-Ribose Polymerase) (Agarose)

Catalogue Number: P3113-01Q-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in 10mM sodium HEPES pH 7.5, 150mM NaCl, 0.1mg/ml BSA, 0.02% sodium azide, 50% glycerol.
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	400 ul
Host name:	Rabbit
Clone:	10g87(46D11)
Isotype:	IgG
Immunogen:	Synthetic peptide corresponding to residues surrounding Gly623 of PARP.
Application:	IP

Overview
Datasheets

Description

Description: PARP, a 116kD nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2,3) and is one of the main cleavage targets of caspase-3 in vivo (4,5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24kD) from the carboxy-terminal catalytic domain (89kD) (2,4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6).

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

PARP1

Uniprot ID

P09874

Gene ID

142

Specificity

Recognizes endogenous levels of total full-length PARP and the large fragment (89kD) produced by caspase cleavage. Species crossreactivity: Human. mouse, rat and monkey

Purification

Purified

Antibody Clonality

Monoclonal

P3113-01Q Datasheet

Price

£697.00

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