PF4 (Platelet Factor 4) (Carboxyfluorescein)

Catalogue Number: P3360-01D-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with Carboxyfluorescein.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	7H2
Isotype:	IgG2b
Immunogen:	Recombinant protein corresponding to Glu32-Ser101 of human PF4, expressed in E. coli.
Application:	FC

Overview
Datasheets

Description

Description: PF4 (Platelet Factor 4, CXCL4) is a member of the CXC chemokine family. Human PF4 is a 101 amino acid(aa) protein with a 32aa signal sequence and a 70aa mature protein. PF4 has homology with IL-8 and b-thromboglobulin. Human and mouse PF4 share a 64% identity. PF4 contains several heparin-binding sites at the C-terminal region. The active protein consists of a tetramer composed of individual PF4 subunits. Megakaryocytes synthesize PF4 and store it as tetramers in alpha- granules. The PF4 tetramers are secreted by activated platelets and can be measured at micromolar levels in serum. In contrast to other CXC chemokines, PF4 lacks chemotactic activity for polymorphonuclear granulocytes. PF4 does not contain an ELR motif. However, many other functions have been observed for PF4. PF4 is involved in monocyte survival and differentiation into macrophages, and it has anti-angiogenic activity. PF4 has been demonstrated to inhibit the binding of FGF-2 to high-affinity receptors, contributing to its subsequent internalization. Cell surface neutrophil chondroitin sulfate chains serve as PF4 binding sites; affinity is controlled by the degree of sulfation of these chains.

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

Recognizes human CXCL4/PF4.

Purification

Protein G purified

Uniprot ID

P02776.2

Antibody Clonality

Monoclonal

P3360-01D Datasheet

Price

£638.00

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