Platelet Derived Growth Factor Receptor, alpha (PDGFRa) (Carboxyfluorescein)

Catalogue Number: P4258-03F-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with Carboxyfluorescein.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	7H37
Isotype:	IgG1
Immunogen:	Human osteosarcoma cell membrane extracts
Application:	FC

Overview
Datasheets

Description

Description: PDGF is a major serum mitogen that can exist as a homo- or heterodimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA, PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Whereas PDGF Rα binds all three PDGF isoforms with high affinity, PDGF Rβ binds PDGF-BB and AB, but not PDGF-AA. Both PDGF Rα and PDGF Rβ are members of the class III subfamily of receptor tyrosine kinases (RTK) that also includes the receptors for M-CSF, SCF and Flt3 ligand. All class III RTKs are characterized by the presence of five immunoglobulin-like domains in their extracellular region and a split kinase domain in their intracellular region. PDGF binding induces receptor homo-and heterodimerization and signal transduction. The expression of the α and β receptors is independently regulated in various cell types. Only PDGF Rα is expressed in oligodendrocyte progenitor cells, mesothelial cell and liver endothelial cells. Soluble PDGF-Rα has been detected in cell conditioned medium and human plasma. Recombinant soluble PDGF Rα binds PDGF with high affinity and is a potent PDGF antagonist.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

PDGFRA

Uniprot ID

P16234

Gene ID

5156

Specificity

Recognizes human PDGFR alpha.

Purification

Protein G purified

Antibody Clonality

Monoclonal

P4258-03F Datasheet

Price

£703.00

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