Recombinant Human PD-1 Protein
Catalogue Number: P613-LET
| Manufacturer: | Leinco Technologies, Inc |
| Shelf Life: | 12 months |
| Type: | Immune Checkpoint Proteins |
| Shipping Condition: | RT |
| Unit(s): | 1 mg, 100 ug, 50 ug, 500 ug |
| Application: | ELISA, WB, FA |
Description
Description: Human Programmed Death 1 (PD-1) is a receptor located on the surface of various cell types including T-cells, B-cells, and some myeloid cells 1 . Its primary function involves regulating the immune system by inhibiting T-cell activation. This process is crucial for promoting self-tolerance and minimizing autoimmune reactions. PD-1 interacts with its ligands, PD-L1 and PD-L2, to effectively suppress T-cell activation and the production of cytokines. This mechanism is frequently exploited by cancers as a means to evade the immune response 2, 3. The interaction between PD-1 and PD-L1 has become a focus in cancer immunotherapy 4. Promising advancements have been made by blocking antibodies targeting PD-1, such as nivolumab and pembrolizumab. These antibodies have shown benefits in treating various cancer types such as melanoma, non-small cell lung cancer, and renal cell carcinoma. They achieve this by enhancing T cell function within the tumor microenvironment 5 - 7. These treatments demonstrate how understanding the role of PD-1, in T-cell activity can lead to the development of immunotherapeutic strategies.
Additional Text
Antibody Clonality
Monoclonal
Storage Note
1 month, 2 to 8 °C under sterile conditions after opening and reconstituting. 1 year from date of receipt, -20 to -80 °C as supplied. 3 months from date of receipt, -20 to -80 °C sterile conditions after opening and reconstituting.
SUPPORT
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PRODUCT
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DELIVERY
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