Recombinant Mouse PD-L1
Catalogue Number: P615-LET
| Manufacturer: | Leinco Technologies, Inc |
| Shelf Life: | 12 months |
| Type: | Immune Checkpoint Proteins |
| Shipping Condition: | Dry Ice |
| Unit(s): | 100 ug, 50 ug |
| Application: | ELISA, WB, FA |
Description
Description: Murine Programmed Death-Ligand 1 (PD-L1) is a protein that is a part of the immune checkpoint pathway which regulates the system used to balance the interaction between tumor cells and immune surveillance1. Unlike PD-1, which is mainly found on T-cells and acts as a receptor, PD-L1 is predominantly present on tumor cells and antigen-presenting cells. It serves as a mediator of immune tolerance by exploiting natural pathways that prevent autoimmunity. Tumors can evade the immune system and avoid detection by expressing PD-L1, inhibiting T-cell activation2. Inflammatory cytokines in the tumor microenvironment further enhance this evasion strategy by increasing PD-L1 expression3. This highlights how tumors adapt and utilize the body's checkpoints for survival and growth. The complex involvement of PD-L1 in both tolerance and cancer immunoevasion emphasizes its significance as a target, for therapy. Blocking PD-L1 aims to dismantle the shield it provides to tumors allowing the immune system to regain its ability to eliminate cells4. While mouse and human PD-L1 are similar in function, there are significant differences in how they are expressed, regulated, and interact at a molecular level. These differences are crucial to accurately translate research findings from mouse models to applications. They highlight the significance of using mouse PD-L1 as a research tool to understand immune regulation mechanisms and develop targeted therapies5. By understanding these species nuances we can better evaluate PD-L1 inhibitors leading to advancements in immunotherapy, for cancer and autoimmune diseases.
Additional Text
Antibody Clonality
Monoclonal
Storage Note
This lyophilized protein is stable for twelve months when stored at -20°C to -70°C. After aseptic reconstitution, this protein may be stored for one month at 2°C to 8°C or for three months at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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