PSMC4 (26S Protease Regulatory Subunit 6B, Proteasome 26S Subunit ATPase 4, 26S Proteasome AAA-ATPase Subunit RPT3, MB67-interacting Protein 1, MIP224, Tat-binding Protein 7, TBP-7, MIP224, TBP7) (Azide Free) (MaxLight 650)
Catalogue Number: P9078-26A-ML650-USB
| Manufacturer: | United States Biological |
| Preservative: | Azide-free |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™650. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 11C606 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Full length recombinant protein corresponding to aa1-419 from human PSMC4 with GST tag. MW of GST alone is 26kD. |
| Application: | ICC, IF, WB, IHC, FLISA |
Description
Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.
Additional Text
Accession Number
AAH00343
Specificity
Recognizes human PSMC4.
Purification
Affinity Purified
Antibody Clonality
Monoclonal
P9078-26A-ML650 Datasheet
SUPPORT
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