Recombinant Human PPM1A protein (His tag)
Catalogue Number: PDEH101083-ELA
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Type: | Protein Phosphatases |
| Alias: | PP2C-ALPHA;PP2C-Alpha;PP2CA;PP2Calpha;PPM1A;PPPM1A;Protein Phosphatase 1A;Protein Phosphatase 2C Isoform Alpha;Protein Phosphatase IA |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
Description
Description: Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.
Additional Text
Gene Name
PPM1A
Gene ID
5494
Uniprot ID
P35813
Protein Tag
HIS Tag
Storage Note
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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