Recombinant Human LEPR Protein(His Tag)

Catalogue Number: PDMH100253-ELA

Manufacturer:	Elabscience
Shelf Life:	12 months
Type:	Other Recombinant Protein
Alias:	CD 295;CD295;CD295 antigen;Db;Fa;HuB219;LEP R;LEP-R;LEPR;LEPR;LEPRD;Leptin receptor;Leptin receptor fatty;Leptin receptor gene related protein;Leptin receptor precursor;Leptin receptor precursor;OB R gene related protein;OB receptor;OB-R;OB-RGRP;obl;Obr
Host Cell:	stable cell line
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug

Overview
Datasheets

Description

Description: Leptin Receptor or CD295 belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight) and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Leptin Receptor/CD295 is transmembrane catalytic receptors found on NPY/AgRP and alpha-MSH/CART neurons in hypothalamic nuclei. Leptin receptors (Ob-Rs) are coded for by one human gene that produces six different isoforms, Ob-Ra-Ob-Rf. Ob-Rs exist as constitutive dimers at physiological expression levels. Only the Ob-Rb isoform can transduce intracellular signals and does so through activation of the JAK2/STAT3, PI 3-K, and MAPK signaling cascades. Activation of Ob-Rs mediates transcriptional regulation of the hypothalamic melanocortin pathway and downregulates endocannabinoid expression. Leptin acts via leptin receptors. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, Ob-Ra (which is involved in the active transport of leptin across the blood-brain barrier) expression is downregulated and the individual may be unresponsive to leptin signals. Ob-R antagonists are of great interest in the development of pharmacological treatments for obesity. Mutations in the Leptin Receptor/CD295 have been associated with an obesity and pituitary dysfunction.

Additional Text

Protein Tag

HIS Tag

Storage Note

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

UniProt ID

P48357-1

PDMH100253 Protocol

PDMH100253 MSDS

Price

£415.00

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