BDNF Alternative Peptide (TrkB Agonist)
Catalogue Number: PG-003-PEP
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Induces Dimerization of TrkB and Exerts Biological Activity similar to BDNF *This is for illustrative purpose.
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We performed a functional comparison test between our BDNF Alternative Peptide (PG-003) and commercially available recombinant BDNF. From the results, PG-003 showed the property which promotes the phosphorylation of TrkB receptor and the expression of NFAT-responsive reporter gene at the same level per molecule compared with recombinant BDNF. The molecular weight of TrkB agonist peptide is approximately 5.1 kDa, which is approximately 2.5 times smaller than that of recombinant BDNF.
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We performed a functional comparison test between our BDNF Alternative Peptide (PG-003) and commercially available recombinant BDNF. From the results, PG-003 showed the property which promotes the phosphorylation of TrkB receptor and the expression of NFAT-responsive reporter gene at the same level per molecule compared with recombinant BDNF. The molecular weight of TrkB agonist peptide is approximately 5.1 kDa, which is approximately 2.5 times smaller than that of recombinant BDNF.
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Applications Data We asked Jiksak Bioengineering Inc. to evaluate the behavior of neurite bundle elongation using their proprietary technology, Nerve OrganoidTM, with BDNF or PG-003. As a result, when PG-003 was used, thicker and longer neurite bundles were formed.
| Manufacturer: | Peptigrowth |
| Molecular Weight: | 5151.66 (Acetate) |
| Physical state: | lyohilized |
| Type: | Peptide |
| Shipping Condition: | Dry Ice |
| Unit(s): | 10 ug, 100 ug, 1000 ug |
| Application: | Cell culture |
Description
Description: PeptiGrowth succeeded in developing a synthetic peptide that works as TrkB agonist and has equivalent fucntion to Brain-Derived Neurotrophic Factor (BDNF). Catalog # PG-003, an alternative peptide to BDNF, can be used as a neurotrophic factor to grow, induce, and maintain neurons derived from neural progenitors. Please note that 10 ug of Catalog # PG-003 is equivalent to ~25 ug of recombinant BDNF due to difference in molecular weight.
Additional Text
PG-003 Biological activity
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