Recombinant Human IL-28A protein(His Tag)
Catalogue Number: PKSH034112-ELA
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Type: | Interleukins |
| Alias: | IFN-lambda;Cytokine Zcyto;Interferon lambda;Ifnl;ZCYTO;IFN-λ;Cytokine Zcyto20;IFN-lambda-2;IFN-λ2;IL-28A;Interferon lambda-2;Interleukin-28A;IL28A;ZCYTO20;IFNL2;ZCYTO20|IFN-λ2 |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Application: | Cell culture |
Description
Description: IL-28A (Interferon-λ2,IFN-λ2), IL-28B/IFN-λ3, and IL-29/IFN-λ1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines. Mature human IL-28A is an approximately 22-25 kDa protein that shares 66% amino acid (aa) sequence identity with mouse and rat IL-28A and shows cross-species activity. It shares 96% and 70% aa sequence identity with human IL-28B and IL-29, respectively. IL-28A promotes the Th1 polarization of dendritic cells in the airway and inhibits Th2 and Th17 mediated inflammation. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration.
Additional Text
Gene ID
282616
Uniprot ID
Q8IZJ0
Gene Name
IFNL2
Protein Tag
HIS Tag
Storage Note
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
PKSH034112 Protocol
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