Recombinant Human TGF beta 3 protein(His Tag)
Catalogue Number: PKSH034198-ELA
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Type: | Transforming Growth Factors |
| Alias: | ARVD;ARVD1;LDS5;RNHF;TGF-B3;TGFB3|ARVD;ARVD1;LDS5;RNHF;TGFB3;TGF-B3 |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Application: | Cell culture |
Description
Description: TGF-beta 3 (transforming growth factor-beta 3) is a member of a TGF-beta superfamily subgroup that is defined by their structural and functional similarities. TGF-beta 3 and its closely related proteins, TGF-beta 1 and beta 2, act as cellular switches to regulate immune function, cell proliferation, and epithelial-mesenchymal transition. The non-redundant biological effects of TGF-beta 3 include involvement in palatogenesis, chondrogenesis, and pulmonary development. Rat TGF-beta 3 cDNA encodes a 412 amino acid (aa) precursor that contains a 23 aa signal peptide and a 389 aa proprotein. TGF-beta 3 is secreted as a latent complex. This latent form of TGF-beta 3 is activated by integrins, thrombospondin-1, plasmin, and matrix metalloproteases. It can also be activated by extreme pH and reactive oxygen species. TGF-beta 3 binds with high affinity to TGF-beta RII, a type II serine/threonine kinase receptor. This receptor then phosphorylates and activates type I serine/threonine kinase receptors, TGF- beta RI or ALK-1, to modulate transcription through Smad phosphorylation. The divergent biological effects exerted by individual TGF-beta isoforms is dependent upon the recruitment of co-receptors (TGF-beta RIII and endoglin) and the subsequent initiation of Smad-dependent or -independent signaling pathways.
Additional Text
Gene ID
7043
Gene Name
TGFB3
Uniprot ID
P10600
Protein Tag
HIS Tag
Storage Note
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
PKSH034198 Protocol
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