Recombinant Human Noggin protein(Fc Tag)
Catalogue Number: PKSH034199-ELA
| Manufacturer: | Elabscience |
| Shelf Life: | 12 months |
| Type: | Bioactive Proteins |
| Alias: | NOG;Noggin;SYM1;symphalangism 1 (proximal);synostoses (multiple) syndrome 1;SYNS1;SYNS1A|NOG;Noggin;SYM1;SYNS1;SYNS1A;symphalangism 1 (proximal);synostoses (multiple) syndrome 1 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug |
| Application: | Cell culture |
Description
Description: Noggin is a secreted protein involved at multiple stages of vertebrate embryonic development including neural induction and is known to exert its effects by inhibiting the bone morphogenetic protein (BMP)-signaling pathway. It binds several BMPs with very high (picomolar) affinities; with a marked preference for BMP2 and BMP4 over BMP7. By binding tightly to BMPs; Noggin prevents BMPs from binding their receptors. Noggin binds the bone morphogenetic proteins (BMP) such as BMP-4 and BMP-7; and inhibits BMP signaling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. Interaction of BMP and its antagonist Noggin governs various developmental and cellular processes; including embryonic dorsal-ventral axis; induction of neural tissue; formation of joints in the skeletal system and neurogenesis in the adult brain. Noggin plays a key role in neural induction by inhibiting BMP4; along with other TGF-β signaling inhibitors such as chordin and follistatin. Mouse knockout experiments have demonstrated that noggin also plays a crucial role in bone development; joint formation; and neural tube fusion.
Additional Text
Gene Name
NOG
Gene ID
9241
Uniprot ID
Q13253
Protein Tag
Fc Tag
Storage Note
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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