Recombinant 2019-nCoV Papain-Like Protease Protein

Catalogue Number: PKSR030472-ELA

Manufacturer:Elabscience
Shelf Life:6 months
Type:Proteases
Alias:Papain-like Protease; PLpro; PL-PRO; pp1a; Replicase polyprotein 1a
Host Cell:E.coli
Shipping Condition:Blue Ice
Unit(s): 10 ug, 50 ug

Description

Description: Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.

Additional Text

Description

Recombinant 2019-nCoV Papain-like Protease is produced by our E.coli expression system and the target gene encoding Glu1564-Lys1878 is expressed.

Price
169.00


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