Recombinant 2019-nCoV S-trimer Protein (His Tag)(D614G)(Active)

Catalogue Number: PKSR030541-ELA

Manufacturer:Elabscience
Shelf Life:6 months
Type:Fusion Protein
Alias:2019-nCov S protein; 2019-nCoV Spike glycoprotein; 2019-nCoV S glycoprotein; SARS-nCoV-2 Spike glycoprotein
Shipping Condition:Blue Ice
Unit(s): 1 mg

Description

Description: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Additional Text

Protein Tag

6xHIS Tag

Description

Recombinant 2019-nCoV S-trimer Protein is produced by our Mammalian expression system and the target gene encoding Cys15-Gln1208(D614G) is expressed with a 6His tag at the C-terminus.