Recombinant SARS-CoV-2 S1+S2 trimer Protein (C-His Tag)(Omicron)
Catalogue Number: PKSV030478-ELA
PKSV030478 Image
PKSV030478 Image
PKSV030478 Image
PKSV030478 Image
PKSV030478 Image
> 95 % as determined by reducing SDS-PAGE.
PKSV030478 Image
1. Loaded Human ACE2-Fc(PKSR030492) on Protein A Biosensor, can bind SARS-CoV-2 S-trimer-His (Omicron, B.1.1.529)(PKSV030478) with an affinity constant of 0.5 nM as determined in BLI assay.
PKSV030478 Image
2. Loaded Anti-SARS-CoV-2 S1 mAb-Fc on Protein A Biosensor, can bind SARS-CoV-2 S-trimer-His (Omicron, B.1.1.529)(PKSV030478) with an affinity constant of 10.7 nM as determined in BLI assay.
PKSV030478 Image
| Manufacturer: | Elabscience |
| Shelf Life: | 6 months |
| Type: | Virus Proteins |
| Alias: | 2019-nCoV Spike protein trimer;Omicron Spike;S trimer protein;SARS-CoV-2 Spike|S trimer protein;2019-nCoV Spike protein trimer;SARS-CoV-2 Spike;Omicron Spike |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
Description
Description: Recombinant SARS-CoV-2 S-trimer Protein is produced by our Mammalian expression system and the target gene encoding Cys15-Gln1208 is expressed with a 6His tag at the C-terminus. A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K and L981F mutations were identified in the SARS-CoV-2 variant (known as Omicron/B.1.1.529 lineage) which emerged in South Africa. Two proline substitutions and furin cleavage site substitutions are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein and abolish the furin cleavage site, respectively.
Additional Text
Gene Name
S
Protein Tag
HIS Tag
Gene ID
43740568
Uniprot ID
P0DTC2
Storage Note
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
PKSV030478 Protocol
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