Biotinylated Human PLAU/uPA Protein (active form) (PLA-HM401B)

Catalogue Number: PLA-HM401B-KAT

Manufacturer:	Kactus
Shelf Life:	12 months
Molecular Weight:	The protein has a predicted MW of 49.3 kDa. Due to protein lysis and glycosylation, the protein migrates to 24-26 kDa, 35-38 kDa and 52-60 kDa based on Bis-Tris PAGE result.
Physical state:	Lyophilized
Type:	Proteases
Alias:	PLAU; Urokinase; ATF; UPA; URK; u-PA; BDPLT5; QPD
Host Cell:	HEK293 cells
Shipping Condition:	RT
Unit(s):	100 ug, 500 ug
Application:	ELISA, WB

Overview
Datasheets

Description

Description: Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC.

Additional Text

Protein Tag

HIS-AviTag™

Short Description

Recombinant Biotinylated Human PLAU/uPA Protein (active form) is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ser21-Leu431, which consists of two chains: Long chain A (Ser21-Phe177) and chain B (Ile179-Leu 431). The long chain A is further cleaved to yield a short chain A (Lys156-Phe 177) and N-Terminus fragment (Ser21-Lys155).

UniProt ID

P00749-1

Storage Note

-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Biological Activity

Immobilized Human uPAR, hFc Tag at 1Oeg/ml (100Oel/well) on the plate. Dose response curve for Biotinylated Human PLAU, His Tag with the EC50 of 13.6ng/ml determined by ELISA. See testing image for detail.

Endotoxin

Less than 1 EU per ug by the LAL method.

PLA-HM401B Datasheet

PLA-HM401B MSDS

Price

£413.00

-

Quantity
Unit Size

Find out about delivery