SARS-ACSMS(M) (residues 408-470/540-573), SARS-Associated Coronavirus Spike Mosaic S(M), recombinant, E. coli
Catalogue Number: PR-1106-JEN
| Manufacturer: | Jena Bioscience |
| Shelf Life: | 12 months |
| Molecular Weight: | 38 kDa |
| Physical state: | Liquid |
| Type: | Spike Proteins |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Application: | ELISA, WB |
Description
Description: SARS-ACSM contains the middle section of the Spike protein immunodominant fragments, amino acids: 408-470, 540-573. SARS-ACSM is purified by proprietary chromatographic techniques. Background: The spike (S) glycoprotein of coronaviruses mediates viral entry into host cells. Spike (S)-glycoprotein of the virus interacts with a cellular receptor and mediates membrane fusion to allow viral entry into susceptible target cells. It is a type 1 viral fusion protein that characteristically contains two heptad repeat regions, denoted HR-N and HR-C, that form coiled-coil structures within the ectodomain of the protein. Previous studies have shown that the two heptad repeat regions can undergo a conformational change from their native state to a 6-helix bundle (trimer of dimers), which mediates fusion of viral and host cell membranes .
Additional Text
Additional Information
Specificity: Immunoreactive with sera of SARSinfected individuals.
Application Notes
Recombinant SARS-ACSM Antigen may be used in ELISA and Western blots, excellent for detection of SARS with minimal specificity problems.
Storage Note
store at -20 °C|12 months|avoid freeze/thaw cycles
PR-1106 MSDS
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