HCV-N-G1b (residues 2-119), Hepatitis C Virus Nucleocapsid Genotype 1b, recombinant, E. coli
Catalogue Number: PR-1132-JEN
| Manufacturer: | Jena Bioscience |
| Shelf Life: | 12 months |
| Molecular Weight: | 40 kDa |
| Physical state: | Liquid |
| Type: | Virus Proteins |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Application: | ELISA, WB |
Description
Description: The protein contains the HCV core nucleocapsid immunodominant regions, amino acids: 2-119. Hepatitis C Virus core proteins are purified by proprietary chromatographic techniques. Background: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER) Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.
Additional Text
Additional Information
Specificity: Immunoreactive with sera of HCV-infected individuals.
Application Notes
Antigen in ELISA and Western blots, excellent antigen for detection of HCV with minimal specificity problems.
Storage Note
store at -20 °C|12 months|avoid freeze/thaw cycles
PR-1132 MSDS
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