HCV-N-G3b (residues 2-119), Hepatitis C Virus Nucleocapsid Genotype 3b, recombinant, E. coli

Catalogue Number: PR-1136-JEN

Manufacturer:	Jena Bioscience
Shelf Life:	12 months
Physical state:	Liquid
Type:	Virus Proteins
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Application:	ELISA, WB

Overview
Datasheets

Description

Description: The protein contains the HCV core nucleocapsid immunodominant regions, amino acids: 1-102. Hepatitis C Virus core proteins are purified by proprietary chromatographic techniques. Background: The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum (ER) Hepatitis C virus (HCV) core is a viral structural protein, it also participates in some cellular processes, including transcriptional regulation. However, the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways In addition, HCV core antigen is a recently developed marker of hepatitis C infection. It is remarkably efficient at establishing persistent infection, suggesting that it has evolved one or more strategies aimed at evading the host immune response. T cell responses, including interferon-gamma production, are severely suppressed in chronic HCV patients. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR.

Additional Text

Additional Information

Specificity: Immunoreactive with sera of HCV-infected individuals.

Application Notes

Antigen in ELISA and Western blots, excellent antigen for detection of HCV with minimal specificity problems.

Storage Note

store at -20 °C|12 months|avoid freeze/thaw cycles

PR-1136 MSDS

PR-1136 Datasheet

Price

£301.00

-

Quantity
Unit Size

Find out about delivery