AF6-RBDGST (residues 1-141), GTP-H-Ras binding cytoplasmic protein, Afadin - Ras-binding domain, human, recombinant, E. coli
Catalogue Number: PR-398-JEN
| Manufacturer: | Jena Bioscience |
| Shelf Life: | 12 months |
| Physical state: | Liquid |
| Type: | Fusion Protein |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug |
Description
Description: The amino terminus of Af6 was identified as the Rasbinding site. Additionally to the Ras-binding Af6 also binds Rap. ZO-1, a protein involved in the formation of tight junctions, also binds to Af6 close to the amino terminus thereby competing with Ras binding. These data suggest a participation of Af6 in the regulation of cell-cell contacts via a Ras-modulated interaction with ZO-1. In contrast to the well characterized effectors Raf, RalGEF, and PI(3)kinase, Af6 is a protein with no enzymatic function. It seems to serve as a scaffolding component for protein complexes. This would represent a new type of Ras effector because Ras binding in this case does not lead to the activation of the enzymatic activity of the effector.
Additional Text
Protein Tag
GST Tag
Accession Number
NM_005936
PR-398 MSDS
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