Mouse TGF-β1 protein, His tag (Animal-Free)
Catalogue Number: PRP1017-ABK
| Manufacturer: | Abbkine |
| Molecular Weight: | 42.7 KD |
| Physical state: | Lyophilized |
| Type: | Transforming Growth Factors |
| Alias: | CED|CEDLAP|DPD1|latency-associated peptide|TGF beta1|TGFB|TGF-b1|TGFB1|TGFbeta|TGFbeta 1|TGF-beta 1|TGF-beta 1 protein|TGF-beta-1|TGF-β1|transforming growth factor beta-1 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 1 mg, 10 ug, 100 ug, 50 ug |
Description
Description: TGF-β1 is a member of the transforming growth factor β (TGF-β) family. The transforming growth factor-β family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-β1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-α and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-β1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-β1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-β1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-β1 also has the opposite effect on cells of myeloid origin. TGF-β1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-β1-mediated growth inhibition, autocrine TGF-β signaling can promote tumorigenesis. Elevated levels of TGF-β1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.
Additional Text
Uniprot ID
P04202
Gene Name
TGFB1
Gene ID
21803
Protein Tag
HIS Tag
Short Description
Mouse TGF-β1 protein, His tag (Animal-Free), expressed in HEK293 Cells
Note
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Mouse TGF beta 1 protein using the buffer we provided not less than 100 µg/mL, which can then be further diluted to other aqueous solutions.
PRP1017 Datasheet
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