Human CD80/B7-1 protein, His tag (Animal-Free)
Catalogue Number: PRP2028-ABK
| Manufacturer: | Abbkine |
| Molecular Weight: | 25.4 KD |
| Type: | Other Proteins |
| Alias: | CD80; Activation B7-1 antigen; B7; BB1; CD28LG1; CD28LGB7-1 antigen; T-lymphocyte activation antigen CD80 |
| Shipping Condition: | RT |
| Unit(s): | 1 mg, 10 ug, 100 ug, 50 ug |
Description
Description: B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses . Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response . Mature mouse B7-1 consists of a 209 amino acid (aa) extracellular domain (ECD) with two immunoglobulin-like domains, a 22 aa transmembrane segment, and a 38 aa cytoplasmic domain . Within the ECD, mouse B7-1 shares 50% and 68% aa sequence identity with human and rat B7-1, respectively. Alternative splicing generates a short isoform that lacks the second Ig-like domain but retains the ability to bind CD28 . Both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4 . B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells.
Additional Text
Gene Name
CD80
Gene ID
941
Uniprot ID
P33681
Short Description
Human CD80/B7-1 protein, His tag (Animal-Free), expressed in HEK293 Cells
PRP2028 Datasheet
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