RAGE (Receptor for Advanced Glycosylation End Products, Advanced Glycosylation End Product-specific Receptor, AGER) (MaxLight 650)

Catalogue Number: R1031-15A-ML650-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™650.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	1C1
Isotype:	IgG2a, kappa
Immunogen:	Full length recombinant protein corresponding to aa23-404 from human RAGE with GST tag. MW of the GST tag alone is 26kD.
Application:	IP, WB, FLISA

Overview
Datasheets

Description

Description: MaxLight™650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. RAGE is a member of the immunoglobulin superfamily of cell surface molecules that bind molecules which have been irreversibly modified by non-enzymatic glycation and oxidation, and are known as advanced glycation end products (AGEs). RAGE is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity. The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune, inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (A beta). Because A beta is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-A beta interaction is thought to result in oxidative stress leading to neuronal degeneration.

Additional Text

Accession Number

AAH20669

Specificity

Recognizes human RAGE.

Purification

Purified

Antibody Clonality

Monoclonal

R1031-15A-ML650 Datasheet

Price

£896.00

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