RANKL (OPGL, ODF, Trance, Receptor Activator of NFkB Ligand) (PE)
Catalogue Number: R1075-12A-PE-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 6D724 (12A380) |
| Isotype: | IgG1, kappa |
| Immunogen: | Fusion protein containing amino acid residues 1-317 of mouse RANKL |
| Application: | FC, ICC, IF, WB, IHC |
Description
Description: TRANCE/OPGL/RANKL/ODF is a recently identified member of tumor necrosis factor family. TRANCE (TNF-related activation-induced cytokine receptor) or RANKL {receptor activator of NF-kB (RANK) ligand} has been implicated in interactions between T cells and dendritic cells (1-2). RANK ligand (RANKL/TRANCE) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). TRANCE/RANKL is also important in T- and B-cell maturation (3). As OPGL/ODF (Osteoprotegerin Ligand/Osteoclast differentiation factor), the same protein can both activate mature osteoclasts and mediate osteoclastogenesis (4,5). OPGL/TRANCE deficient mice show severe osteoporesis and complete absence of osteoclasts as a result of lack of osteogenesis (3).
Additional Text
Uniprot ID
O35235
Gene Name
TNFSF11
Gene ID
21943
Purification
Protein G purified
Antibody Clonality
Monoclonal
R1075-12A-PE Datasheet
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