Retinal Pigment Epithelium Specific Protein (Retinal Pigment Epithelium-specific 65kD Protein, RPE65, All-trans-retinyl-palmitate Hydrolase, LCA2, mRPE65, rd12, Retinol Isomerase, Retinoid Isomerohydrolase, RP20, sRPE65) (Biotin)
Catalogue Number: R1659-70B-USB
| Manufacturer: | United States Biological |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 200 ul |
| Host name: | Mouse |
| Clone: | 8B99 (401.8B11.3D9) |
| Isotype: | IgG1, kappa |
| Immunogen: | Bovine RPE microsomal membrane proteins. Cellular Localization: Cytoplasmic, microsomeal and cell membrane. Species Sequence Homology: birds; 89%, zebrafish; 74%, sea lamprey; 71% |
| Application: | ICC, WB, IHC |
Description
Description: Highly conserved among vertebrate species, RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
Additional Text
Purification
Protein A purified
Antibody Clonality
Monoclonal
R1659-70B Datasheet
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