Retinal Pigment Epithelium Specific Protein (Retinal Pigment Epithelium-specific 65kD Protein, RPE65, All-trans-retinyl-palmitate Hydrolase, LCA2, mRPE65, rd12, Retinol Isomerase, Retinoid Isomerohydrolase, RP20, sRPE65) (HRP)
Catalogue Number: R1659-70D-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.4. Labeled with HRP. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 8B99 (401.8B11.3D9) |
| Isotype: | IgG1, kappa |
| Immunogen: | Bovine RPE microsomal membrane proteins. Cellular Localization: Cytoplasmic, microsomeal and cell membrane. Species Sequence Homology: birds; 89%, zebrafish; 74%, sea lamprey; 71% |
| Application: | WB, IHC |
Description
Description: Highly conserved among vertebrate species, RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
Additional Text
Caution
FOR RESEARCH USE ONLY
Gene Name
RPE65
Specificity
Recognizes RPE65. Tested in bovine, porcine, human and murine.
Purification
Protein G purified
Gene ID
282043
Uniprot ID
Q28175
Antibody Clonality
Monoclonal
R1659-70D Datasheet
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