Gefitinib-based PROTAC 3

Catalogue Number: S0070-SEL

Manufacturer:Selleck Chemicals
Shelf Life:36 months
Molecular Formula:C47H57ClFN7O8S
Type:Biochemicals
Shipping Condition:Blue Ice
Unit(s): 25 mg, 5 mg, 10 mM/1 ml, 100 mg

Additional Text

Short Description

Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker induces degradation of EGFR and mutants with DC50 of 11.7 nM and 22.3 nM in HCC827(Exon 19 del) and H3255 (L858R) cells, respectively.

Smile String

CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCCCCOC4=C(C=C5C(=C4)C(=NC=N5)NC6=CC(=C(C=C6)F)Cl)OC)O

Storage Note

3 years -20°C powder

Price
£794.00


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