10-Deacetyl-7-xylosyl paclitaxel
Catalogue Number: S0563-SEL
| Manufacturer: | Selleck Chemicals |
| Shelf Life: | 36 months |
| Molecular Formula: | C50H57NO17 |
| Type: | Biochemicals |
| Alias: | 10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 mg, 5 mg |
Additional Text
Short Description
10-Deacetyl-7-xylosyl paclitaxel (10-Deacetyl-7-xylosyltaxol, 7-xylosyl-10-deacetylpaclitaxel), a derivative of paclitaxel and naturally occurring xyloside isolated from Taxus chinensis, causes significant mitotic arrest in PC-3 cells followed by up-regulating expression of pro-apoptotic Bax and Bad protein, as well as down-regulating expression of anti-apoptotic Bcl-2 and Bcl-XL , which leads to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9.
Smile String
CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OC8C(C(C(CO8)O)O)O)C)O
Storage Note
3 years -20°C powder
Inhibitor Handling Instructions
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