SERPINB9 (Serine/Cysteine Proteinase Inhibitor, Clade B, Member 9, Serpin B9, PI9, Cytoplasmic Antiproteinase 3, CAP-3, CAP3) (MaxLight 490)

Catalogue Number: S1000-89A-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	7D8
Isotype:	IgG1
Immunogen:	Recombinant PI-9 produced in P. pastoris.
Application:	FC, WB, IHC

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. PI-9 (proteinase inhibitor 9), also known as SerpinB9, is a 42kD intracellular nucleocytoplasmic serpin expressed in cytotoxic lymphocytes (CTLs), natural killer (NK) cells, monocyte-derived dendritic cells (DCs), and to a lesser extent in B cells and myeloid cells. Granzyme B (grB) is a serine protease highly expressed by CTLs and NK cells, which is endocytosed by virus-infected and malignant target cells. The subsequent release of grB from the endocytic vesicles into the cytoplasm of the target cells, triggers grB-mediated apoptosis, through cleavage of various cytoplasmic or nuclear proteins. PI-9, up-regulated in response to grB production and degranulation, has been identified as a potent inhibitor of Granzyme B-mediated apoptosis, providing a vital self-protection mechanism against the premature apoptosis of CTLs and NK cells by grB, which may escape into the cytoplasm of the effector cells themselves.

Additional Text

Specificity

Recognizes human PI-9 at ~42kD under reducing conditions. Does not react with porcine or mouse PI-9.

Purification

Protein G purified

Antibody Clonality

Monoclonal

S1000-89A-ML490 Datasheet

Price

£850.00

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