Lenalidomide
Catalogue Number: S1029-SEL
| Manufacturer: | Selleck Chemicals |
| Shelf Life: | 24 months |
| Molecular Formula: | C13H13N3O3 |
| Type: | Other Inhibitors |
| Alias: | CC-5013 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 10mM (1mL in DMSO), 50 mg, 500 mg, 1 g |
Additional Text
Caution
FOR RESEARCH USE ONLY
Short Description
Lenalidomide is a TNF-α secretion inhibitor with IC50 of 13 nM in PBMCs. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide promotes cleaved caspase-3 expression and inhibit VEGF expression and induces apoptosis.
Smile String
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N
Storage Note
2 years -80 in solvent
Inhibitor Handling Instructions
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