Sunitinib malate
Catalogue Number: S1042-SEL
| Manufacturer: | Selleck Chemicals |
| Shelf Life: | 24 months |
| Molecular Formula: | C22H27FN4O2.C4H6O5 |
| Type: | Other Inhibitors |
| Alias: | SU11248 malate |
| Shipping Condition: | Blue Ice |
| Unit(s): | 500 mg, 10mM (1mL in DMSO), 1 g, 100 mg |
Additional Text
Caution
FOR RESEARCH USE ONLY
Smile String
CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C.C(C(C(=O)O)O)C(=O)O
Short Description
Sunitinib malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.
Storage Note
2 years -80 in solvent
Inhibitor Handling Instructions
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