Crizotinib
Catalogue Number: S1068-SEL
| Manufacturer: | Selleck Chemicals |
| Type: | Other Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 5 mg, 50 mg, 10 mM/ 1 mL, 200 mg, 1 g |
Description
Description: Crizotinib is a potent inhibitor of c-Met and ALK with IC50 of 11 nM and 24 nM in cell-based assays, respectively. It is also a potent ROS1 inhibitor with Ki value less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
Additional Text
Caution
FOR RESEARCH USE ONLY
S1068 MSDS
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