Sheep anti Human Vav-2 SHD

Catalogue Number: S115P-EXA

Manufacturer:	ExAlpha
Type:	Primary Antibody
Alias:	VAV-2; Guanine nucleotide exchange factor VAV-2, Src homology 2 and 3 (SH2 & SH3) domains
Shipping Condition:	Blue Ice
Unit(s):	250 ug
Host name:	Sheep
Clone:
Isotype:	IgG
Immunogen:	A his tagged fusion protein Vav-2 corresponding to amino acid sequence 578 - 878 and having a molecular weight of 100kD
Application:	IP, WB

Overview

Description

Description: The immunogen used for the anti-human Vav-2 SHD region was a his tagged fusion protein Vav-2 corresponding to amino acid sequence 578 - 878 and having a molecular weight of 100kD. Vav-2 has a molecular weight of 100 kD and shares over a 50% homology at the amino acid and nucleic acid level with Vav. Vav-2 is a ubiquitously expressed structural homolog of the Vav protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl- homology ((DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type vav-2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a Vav-2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.

Additional Text

Gene ID

7410

Gene Name

VAV2

Uniprot ID

P52735

Purification

Ammonium Sulfate Precipitated

Antibody Clonality

Polyclonal

Application Notes

Applications: Western Blot 1:5,000. Immunoprecipitation -Empirical

Storage Note

Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

Price

£322.00

-

Quantity
Unit Size

Find out about delivery