PF-4708671
Catalogue Number: S2163-SEL
| Manufacturer: | Selleck Chemicals |
| Shelf Life: | 24 months |
| Molecular Formula: | C19H21F3N6 |
| Type: | Kinase Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 10 mM/ 1 mL, 50 mg, 1 g |
Additional Text
Caution
FOR RESEARCH USE ONLY
Short Description
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) with Ki/IC50 of 20 nM/160 nM in cell-free assays, 400-fold greater selectivity for S6K1 than S6K2, and 4- and >20-fold selectivity for S6K1 than MSK1 and RSK1/2, respectively. PF-4708671 induces autophagy. First S6K1-specific inhibitor to be reported.
Smile String
CCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F
Storage Note
2 years -80 in solvent
Inhibitor Handling Instructions
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