SOS1 (Son of Sevenless Homolog 1, SOS-1) (HRP)
Catalogue Number: S5360-18A-HRP-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with horseradish peroxidase (HRP). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 10F445 (SOS-1) |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to amino acids, THPSMHRDGPPLLENAHSS of human Son of Sevenless 1. |
| Application: | ELISA, IF, WB |
Description
Description: SOS1 (son of sevenless homolog 1) is a ubiquitously expressed 150kD intracellular protein and bifunctional guanine nucleotide exchange factor (GEF), which plays a role in growth and differentiation signalling pathways and in actin reorganization, by acting as a regulator of Ras and Rac/Rho GTPases. Mutations in the SOS1 gene are responsible for the rare oral overgrowth condition known as gingival fibromatosis 1 (GINGF1), and also the cause of the relatively common autosomal dominant disorder Noonan syndrome type 4 (NS4), characterized by short stature, congenital heart malformation, bleeding diathesis and distinctive facial features.
Additional Text
Gene Name
SOS1
Uniprot ID
Q07889
Specificity
Recognizes human Son of Sevenless 1. Species Crossreactivity: mouse
Gene ID
6654
Purification
Protein A purified
Antibody Clonality
Monoclonal
S5360-18A-HRP Datasheet
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