Leptomycin B
Catalogue Number: S7580-SEL
| Manufacturer: | Selleck Chemicals |
| Shelf Life: | 36 months |
| Molecular Formula: | C33H48O6 |
| Type: | Biochemicals |
| Alias: | LMB, CI 940, Elactocin, Mantuamycin, NSC 364372 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 5 mg, 10 mM/1 ml |
Additional Text
Short Description
Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM-10 nM.
Smile String
CCC(/C=C/C1OC(=O)C=CC1C)=C/C(C)C/C=C/C(C)=C/C(C)C(=O)C(C)C(O)C(C)CC(C)=CC(O)=O
Storage Note
3 years -20°C powder
Inhibitor Handling Instructions
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