Leptomycin B
Catalogue Number: S7580-SEL
| Manufacturer: | Selleck Chemicals |
| Type: | Biochemicals |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 5 mg, 10 mM/1 ml |
Description
Description: Leptomycin B (LMB, CI 940, Elactocin, Mantuamycin, NSC 364372) is a potent antifungal antibiotic isolated from Streptomyces and acts as a specific inhibitor of the nuclear export factor CRM1. Leptomycin B rapidly induces cytotoxic effects in cancer cell lines via covalent inhibition of CRM1 with IC50 values of 0.1 nM-10 nM.
Inhibitor Handling Instructions
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