Ripretinib
Catalogue Number: S8757-SEL
| Manufacturer: | Selleck Chemicals |
| Shelf Life: | 36 months |
| Molecular Formula: | C24H21BrFN5O2 |
| Type: | Other Inhibitors |
| Alias: | DCC-2618 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 25 mg, 5 mg, 10mM (1mL in DMSO), 100 mg, 1 g |
Additional Text
Smile String
CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC
Short Description
Ripretinib is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) Kit (c-Kit) and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM for WT Kit (c-Kit), V654A Kit (c-Kit), T670I Kit (c-Kit), D816H Kit (c-Kit) and D816V Kit (c-Kit), respectively.
Storage Note
3 years -20°C powder
Inhibitor Handling Instructions
SUPPORT
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PRODUCT
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DELIVERY
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