Syk, p72 (PE)
Catalogue Number: S9100-02B-PE-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | SYK-01 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant fragment corresponding to amino acids 5-360 of human Syk. |
| Application: | IP, WB |
Description
Description: Syk plays an important role in mast cell response, initiated by the aggregation of the IgE high affinity receptor Fc epsilon R1. Phosphorylation of ITAMs within Fc receptor R1 by another tyrosine kinase Lyn, results in the recruitment of Syk, which is then responsible for the further phosphorylation of numerous target proteins within many different signal transduction pathwaysFurther studies have shown that Syk also plays a major role in B cell receptor-mediated apoptosis, proliferation and haematopoiesis. Syk is also reported to associate with protein kinase C alpha during platelet activation.
Additional Text
Gene ID
6850
Gene Name
SYK
Uniprot ID
P43405
Specificity
Recognizes protein tyrosine kinase p72syk (Syk), a 72kD non-receptor tyrosine kinase, critical for immunoreceptor signaling in haematopoietic cells, but also expressed by nonhaematopoietic cells, including fibroblasts, endothelial cells, and hepatocytes. Species Cross Reactivity: Human, mouse and rat.
Purification
Protein A purified
Antibody Clonality
Monoclonal
S9100-02B-PE Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations