Human SMPD1 Protein (SMD-HB101)
Catalogue Number: SMD-HB101-KAT
SMD-HB101 Image
SMD-HB101 Image
SMD-HB101 Image
Human SMPD1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
SMD-HB101 Image
Measured by its ability to cleave 2-N-Hexadecanoylamino-4-nitrophenylphosphorylcholine (HNPPC). The specific activity is > 1500 pmol/min/ug.
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 66.53 kDa. Due to glycosylation, the protein migrates to 67-70 kDa based on Bis-Tris PAGE result. |
| Physical state: | Liquid |
| Type: | Other Enzymes |
| Alias: | SMPD1 |
| Host Cell: | Baculovirus-Insect Cells(Sf9) |
| Shipping Condition: | Dry Ice |
| Unit(s): | 100 ug, 500 ug |
| Application: | WB |
Description
Description: Sphingomyelin phosphodiesterase 1 (SMPD1) converts sphingomyelin into ceramide and phosphocholine; hence, loss of SMPD1 function causes abnormal accumulation of sphingomyelin in lysosomes, which results in the lipid-storage disorder Niemann-Pick disease (types A and B). SMPD1 activity is dependent on zinc, which is coordinated at the active site of the enzyme.
Additional Text
Accession Number
NP_000534.3
Protein Tag
HIS Tag
Storage Note
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Endotoxin
Less than 1 EU per µg by the LAL method.
Short Description
Recombinant Human SMPD1 Protein is expressed from Baculovirus-Insect Cells(Sf9) with His tag at the C-terminus.It contains Met1-Pro628.
SMD-HB101 Datasheet
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