T-box (T-bet, TBX21) (Carboxyfluorescein)

Catalogue Number: T1848-45-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a lyophilized powder in 25ug antibody, 1ml saline, 0.5% BSA, 0.09% sodium azide. Reconstitute with 40-50% glycerol, PBS. Labeled with Carboxyfluorescein.
Type:	Monoclonal Primary Antibody - Conjugated
Alias:	TBET\|T-bet\|TBLYM\|T-box expressed in T cells\|T-box protein 21\|T-box transcription factor TBX21\|T-cell-specific T-box transcription factor T-bet\|T-PET\|transcription factor TBLYM
Shipping Condition:	Blue Ice
Unit(s):	100 Tests
Host name:	Mouse
Clone:	9H183
Isotype:	IgG1
Immunogen:	Human T-bet/TBX21.
Application:	FC

Overview
Datasheets

Description

Description: T-box expressed in T cells (T-bet), also known as T-box transcription factor TBX21, is a 62kD member of the T-box family of transcription factors and the Tbr1 subfamily. T-bet is a nuclear protein that is Th1-cell specific. Human T-bet is 535aa in length and contains a T-box DNA binding domain (aa136-327; SwissProt Accession # Q9UL17). Human T-bet shares 88% aa sequence identity with mouse T-bet. Northern blot analysis revealed that it is expressed only in the lung, thymus and spleen. Functionally, T-bet controls the expression of the Th1 cytokine, IFN-gamma, and initiates Th1 lineage development from naive Th precursor cells by both activating Th1 genetic programs and by repressing the opposing Th2 programs.

Additional Text

Caution

FOR RESEARCH USE ONLY

Gene Name

TBX21

Uniprot ID

Q9UL17

Gene ID

30009

Specificity

Recognizes human T-bet/TBX21.

Purification

Affinity Purified

Antibody Clonality

Monoclonal

T1848-45 Datasheet

Price

£599.00

-

Quantity
Unit Size

Find out about delivery