Anti-Mouse TCR β chain (TCR) - Purified
Catalogue Number: T648-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | RT |
| Unit(s): | 500 ug |
| Host name: | |
| Clone: | H57-597 |
| Isotype: | |
| Immunogen: | |
| Application: | FC, IHC-P, Depl, Stim-Co, Img |
Description
Description: TCRβ antibody, clone H57-597, recognizes the beta chain of the T cell receptor (TCRβ), expressed on αβ thymocytes and T lymphocytes, as well as natural killer T (NKT) cells1. TCRβ is a transmembrane protein that consists of an amino-terminal variable region, a constant region, and a stalk segment covalently linked to the TCR alpha chain (TCRα) via a disulfide bond2. TCRα/β does not contain signaling domains and is instead noncovalently associated with the CD3 complex (TCR-CD3), essential for TCR signaling3,4. TCRα/β recognizes antigens bound to major histocompatibility complex (MHC) molecules, resulting in phosphorylation of CD3 ITAMs and subsequent T cell activation, proliferation, and survival5,6.
Additional Text
Concentration
0.5 mg/ml
Purification
Purified
Antibody Clonality
Monoclonal
Storage Note
This antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at - 20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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