TLR5 (Toll Like Receptor 5, Toll-like Receptor 5 Precursor, TLR 5, TLR-5, FLJ10052, MGC126430, MGC126431, Toll/interleukin 1 Receptor-like Protein 3, TIL3)

Catalogue Number: T8050-41-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Type:	Monoclonal Primary Antibody - Unconjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Mouse
Clone:	4H280
Isotype:	IgG2a
Immunogen:	Synthetic peptide corresponding to a portion of human TLR5 (KLH coupled).
Application:	FC, WB

Overview
Datasheets

Description

Description: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TRL family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). TLR3 cDNA codes for a protein with approximate molecular weight of 120kD (4). TLR3 has a restricted expression pattern being expressed in dendritic cells (DC) (4-6). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes (6). The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.

Additional Text

Caution

FOR RESEARCH USE ONLY

Accession Number

NP_003259

Specificity

Recognizes human TLR3 (Toll Like Receptor 5). Species Crossreactivity: Human, mouse

Purification

Protein G purified

Antibody Clonality

Monoclonal

T8050-41 Datasheet

Price

£586.00

-

Quantity
Unit Size

Find out about delivery