TLR5 (Toll-like Receptor 5, Toll/Interleukin-1 Receptor-like Protein 3, TIL3)
Catalogue Number: T8050-45T-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a lyophilized powder in PBS, trehalose. Reconstitute with sterile PBS to 0.5mg/ml. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | MELIOS|SLE1|SLEB1|systemic lupus erythematosus susceptibility 1|TIL3|toll/interleukin-1 receptor-like protein 3|toll-like receptor 5 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | 12K188 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant protein corresponding to Ile21-Phe115 from human TLR5 expressed in E. coli. |
| Application: | FC, IHC |
Description
Description: TLR5 is an ~100kD type I transmembrane glycoprotein of the Toll-like receptor family. It is expressed on mucosal epithelia in the gastrointestinal tract, airways, and other areas of potential bacterial contact and recognizes bacterial flagellin. Expression is also reported on monocytes, immature dendritic cells, and CD4+ T lymphocytes. The region of human TLR5 used as an immunogen includes the first 2 of 16 leucine-rich repeats and shares 72% aa identity with mouse and rat TLR5. This region is outside of the flagellin binding region. Flagellin engagement induces dimerization and intracellular signaling via MyD88.
Additional Text
Caution
FOR RESEARCH USE ONLY
Gene Name
TLR5
Specificity
Recognizes human TLR5. Species sequence homology: Recombinant human TLR1, 2, 3, 4, 7, 8, recombinant mouse TLR5, 6, or rhTIRAP (5%).
Purification
Protein G purified
Uniprot ID
O60602
Gene ID
7100
Antibody Clonality
Monoclonal
T8050-45T Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations