Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH, TYH, TRH, TYH, PAH, PH8, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase) (HRP)
Catalogue Number: T9014-70A-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.5, before the addition of glycerol to 40%. No preservatives added. Labeled with HRP. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | indoleacetic acid-5-hydroxylase|L-tryptophan hydroxylase|TPRH|TRPH|tryptophan 5-hydroxylase 1|tryptophan 5-monooxygenase 1|tryptophan hydroxylase (tryptophan 5-monooxygenase) |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 2Q122 (PH8) |
| Isotype: | IgG1 |
| Immunogen: | Human phenylalanine hydroxylase sequence between aa139-155 (NM_004179.1). |
| Application: | IP, WB, IHC |
Description
Description: Tyrosine hydroxylase (TYH) is the enzyme which converts tyrosine to dihydroxyphenylalanine (L-dopa), a precursor of the catecholamine neurotransmitters dopamine, noradrenaline and adrenaline. Tryptophan hydroxylase (TRH) is the enzyme that converts 5-hydroxytryptophan to serotonin. In fresh tissue, the antibody binds to TYH and TRH. So it is a marker for TYH-containing catecholaminergic neurons and serotonergic neurons. Tryptophan hydroxylase (TRH) can be used as a marker for serotonin as it converts 5-hydroxytryptophan to serotonin. Serotonin is rapidly metabolized and is unable to be detected by anti-serotonin antibodies in post-mortem tissue. In human tissue that has been formalin-fixed, due to a change in the antigenic determinant of tyrosine hydroxylase (TYH), the antibody binds only tryptophan hydroxylase (TRH). Used to specifically identify serotonergic neurons in fixed human tissue. Phenylalanine hydroxylase (PAH) can also be detected in hepatic tissue sections.
Additional Text
Caution
FOR RESEARCH USE ONLY
Gene ID
7166
Gene Name
TPH1
Uniprot ID
P17752
Specificity
Binds a common epitope of Tryptophan hydroxylase (TRH), Tyrosine hydroxylase (TYH) and Phenylalanine hydroxylase (PAH).
Accession Number
NM_004179.1
Purification
Protein G purified
Antibody Clonality
Monoclonal
T9014-70A Datasheet
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