Tumor Necrosis Factor Receptor 1, p55 (TNFR 1, CD120a, MGC19588, p55, p55 R, TNFR55, Tumor Necrosis Factor alpha Receptor, Tumor Necrosis Factor Binding Protein 1, TBP1, Tumor Necrosis Factor Receptor Superfamily Member 1A, TNFRSF1a) (MaxLight 490)
Catalogue Number: T9161-06B-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 3H3103 (H398) |
| Isotype: | IgG2a |
| Immunogen: | Recombinant protein corresponding to human tumor necrosis factor receptor type 1. |
| Application: | FC, WB, RIA, FLISA |
Description
Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. The immunoregulatory cytokine tumor necrosis factor alpha (TNFa) recognizes two cell surface receptors. TNF-R1 (also known as CD120a) has an apparent molecular mass of 55/60kD and is constitutively expressed on all nucleated cells, whereas TNF R2 (also known as CD120b) with an apparent molecular mass of 75/80kD, is restricted to hematopoietic cells. TNF-R2 directs TNFa mediated activation and proliferation of T lymphocytes. An autocrine role for TNF and TNF-R2 is implicated in hematopoietic malignancies, and the TNF-R2 locus is a translocation target in several leukemias, suggesting a role for TNF-R2 in the development of certain leukemias.
Additional Text
Uniprot ID
P19438
Gene Name
TNFRSF1A
Gene ID
7132
Specificity
Recognizes an extracellular domain of the 55kD human TNF receptor. No binding occurs to the 75kD TNF receptor (CD120b). CD120a is weakly expressed by momocytes and granulocytes. Inhibits the biological activity of both natural and recombinant human TNFalpha and TNFbeta. Species Crossreactivity: rabbit
Purification
Protein A purified
Antibody Clonality
Monoclonal
T9161-06B-ML490 Datasheet
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