Goat anti Mouse Disabled-1 (NT)
Catalogue Number: U100P-EXA
| Manufacturer: | ExAlpha |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | Disabled homolog 1; DAB1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 250 ug |
| Host name: | Goat |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | |
| Application: | WB |
Description
Description: Disruption of the disabled-1 gene (Dab1) results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. Disabled 1 acts downstream of reelin in a signalling pathway.
Additional Text
Gene Name
DAB1
Gene ID
13131
Uniprot ID
P97318
Purification
Ammonium Sulfate Precipitated
Antibody Clonality
Polyclonal
Application Notes
Immunoblotting at 1-5 µg/ml, Immunoprecipitation at 5-10µg/ml. Optimal concentration should be evaluated by serial dilutions.
Storage Note
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
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