Biotin Mouse Anti-human HLA-G Antibody *MEM-G/1, monoclonal*

Biotin Mouse Anti-human HLA-G Antibody MEM-G/1, monoclonal

Catalogue Number: V1031160-AAT

Manufacturer:	AAT Bioquest
Shelf Life:	12 months
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	0.1 mg
Host name:	Mouse
Clone:	MEM-G/1
Isotype:
Immunogen:

Overview
Datasheets

Description

Description: HLA class I histocompatibility antigen, α chain G is a 38 kDa transmembrane protein that can be found in the recycling endosome membrane, filopodium membrane and early endosome membrane of cells.It is alternatively called HLA G antigen and MHC class I antigen G. In humans, HLA G antigen acts to positively regulate natural killer cell cytokine production, cellular senescence and macrophage cytokine production while also represses G0 to G1 transition, angiogenesis and protein kinase B signaling. Sequencing of HLA G antigen has supported it contains 3 types of conserved structural units: Ig-like C1-type, cytoplasmic and extracellular domain. HLA G is the subject of extensive research stemming from the fact that it is involved with the immune response-inhibiting cell surface receptor signaling pathway, type I interferon signaling pathway and interferon-γ-mediated signaling pathway. It has been thought to be involved with important functions such as protein homodimerization activity. HLA G antigen binds with CD8 receptor, identical protein and signaling receptor. It is an integral part of organismal processes, for example, peripheral B cell tolerance induction, cellular defense response and protection from natural killer cell mediated cytotoxicity, and also, takes part in processes such as immune response.

Additional Text

Antibody Clonality

Monoclonal

Storage Note

See Protocol|12 months

V1031160 Protocol

Price

£723.00

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Quantity
Unit Size

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