Biotin Mouse Anti-human/pig β2-Microglobulin Antibody *B2M-02, monoclonal*
Catalogue Number: V103185-AAT
| Manufacturer: | AAT Bioquest |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | Mouse |
| Clone: | B2M-02 |
| Isotype: | |
| Immunogen: |
Description
Description: β-2-Microglobulin is a 16 kDa protein that can be located in the tertiary granule lumen, extracellular exosome and recycling endosome membrane of cells. Sequencing of β-2-microglobulin has shown it contains a primary structural unit, the Ig-like C1-type domain. β-2-Microglobulin recognizes identical protein. It downregulates epithelial cell proliferation, neurogenesis and neuron projection development. But on the other hand, it also positively regulates cellular senescence, transferrin receptor binding and T cell mediated cytotoxicity. β-2-Microglobulin has been found to be involved in organismal processes, for example, modulation of age-related behavioral decline, response to molecule of bacterial origin and cellular response to iron(III) ion. β-2-Microglobulin is the subject of extensive research because of the fact that it plays a role in the interferon-γ-mediated signaling pathway. β-2-microglobulin is clinically significant because abnormalities in its function have been associated with diseases like Amyloidosis 8 (AMYL8) and Immunodeficiency 43 (IMD43). Amyloidosis 8, an autosomal dominant inheritancedisorder characterized by proteinuria, hypertensive disorder and edema, has especially been of interest to researchers.
Additional Text
Antibody Clonality
Monoclonal
Storage Note
See Protocol|12 months
V103185 Protocol
SUPPORT
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DELIVERY
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