SARS-CoV-2 Spike Peptide (RTQLPPAYTNSFTRG)

Catalogue Number: VGP1003-ABG

Manufacturer:	Abcepta
Type:	Peptide
Alias:	SARS-CoV-2 Spike Glycoprotein , E2 , Peplomer
Shipping Condition:	Blue Ice
Unit(s):	100 ug

Overview
Datasheets

Description

Description: SARS-CoV-2 is part of the Coronaviridae family, whose members are named after their crown-like appearance under the electron microscope caused by the surface glycoproteins that decorate the virus. Coronaviruses have a large (30+ kb) single-stranded positivesense RNA genome encoding for several open reading frames. One frame encodes the spike protein (S protein), a class I fusion protein that mediates attachment of the virus to cell surface receptors followed by uptake into endosomes (for most coronaviruses). Proteolytic cleavage of the S protein and fusion of viral and endosomal membranes trigger release of viral RNA into the cytosol. We know now from studies on SARS-CoV-1 and the related MERS-CoV vaccines that the S protein on the surface of the virus is an ideal target for a vaccine. In SARS-CoV-1 and SARS-CoV-2, this protein interacts with the receptor ACE2, and antibodies targeting the spike can interfere with this binding, thereby neutralizing the virus. The structure of the S protein of SARS-CoV-2 was solved in record time at high resolution, contributing to our understanding of this vaccine target. More than 90 vaccines are being developed against SARS-CoV-2 by research teams in companies and universities across the world.

Additional Text

Gene ID

43740568

Uniprot ID

P0DTC2

Gene Name

Short Description

Coronavirus Peptide

Accession Number

AAP41037.1

Preparation

Lyophilized

VGP1003 Datasheet

Price

£296.00

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